• A letter from Will LewisTo our shareholders
  • Our PurposePutting patients first in everything we do
  • Our CultureTogether, we amount to more
  • Our Four PillarsPursuing unmet need, no matter the challenge

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2022 Annual Report

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Our Purpose

Putting patients first in everything we do

  • Completed enrollment in the ARISE frontline study in patients with MAC lung disease
  • Completed enrollment in the ASPEN study in adults with bronchiectasis
  • Advanced TPIP into Phase 2 trials in PH-ILD and PAH
  • Announced Phase 2 brensocatib PK/PD CF data
  • Announced plans to study brensocatib in CRSsNP
~800

employees around
the globe

Great Place to
Work Certification

in the U.S. for second year in a row

No. 1

Science Top Employer
for second year in a row

#90

on 2022 Deloitte Technology
Fast 500 List, North America

No. 2

on 2022 Best Workplaces
in Biopharma™, Small
and Medium list

One of the 2022
Best Workplaces

in New York™ (including companies
headquartered in NY, NJ, and CT)

Technology Fast 500 2022 North America
Great Place to Work Certified July 2022 - July 2023
CarolLiving with Mac Lung Disease

Carol is a MAC lung disease patient who has been compensated for her time.

Carol first sensed that something was wrong when she noticed a constant need to clear her throat. She mentioned it during her annual physical in early 2014, and her doctor ordered a chest X-ray to rule out allergies as the cause. Upon reviewing the results of the X-ray, he diagnosed her with bronchiectasis and referred her to a pulmonologist. Over the next several months, the pulmonologist conducted quarterly computed tomography (CT) scans on Carol’s lungs, which showed increasing signs of inflammation. Frustrated by his lack of urgency and growing uneasy with the possibilities she was uncovering online, she pushed for a sputum test. The results showed that she had Mycobacterium avium complex (MAC) lung disease.

Learn more about Carol’s story here

“You have to be your own advocate, so learn as much as you can on your own. What you find may raise more questions, but that’s what your doctor is there for.”

KelseyLiving with bronchiectasis

Kelsey is a bronchiectasis patient who has been compensated for her time.

After having undergone radiation treatment to her lung in 2016, Kelsey began experiencing a crackling sound when breathing, especially while lying down. Her specialist reviewed her CT scans, but despite noticing some damage from the radiation, did not make a diagnosis or advise further treatment. For the next few years, Kelsey tried to deal with it as best as possible. But as time went on, she began coughing and needing to clear her throat more than usual. What started as a dry cough became a mucus-producing cough that was more persistent with physical activity. Her doctor would prescribe antibiotics that would help for a few months, but the symptoms would always return. In 2021, after coughing up blood one day, Kelsey’s boyfriend urged her to go back to the doctor. Her original specialist referred her to a primary care physician, who referred her to a pulmonologist. Finally, after five years of searching for an answer, Kelsey’s CT and pulmonary function test results confirmed that she had non-cystic fibrosis bronchiectasis.

Learn more about Kelsey’s story here

“For me, it’s important not to make this my identity. I want to feel like I’m living my life and not focusing only on being a sick person.”

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2022 Annual Report

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